Anticancer drug development - download pdf or read online

By Bruce C Baguley; David J Kerr

ISBN-10: 0120726513

ISBN-13: 9780120726516

Show description

Read or Download Anticancer drug development PDF

Best oncology books

Endocrine Neoplasia by Insoo Suh, Electron Kebebew (auth.), Cord Sturgeon (eds.) PDF

Endocrine Neoplasia offers a large evaluation of the neoplastic stipulations of extracranial endocrine glands now not excited by replica. Benign and malignant tumors of the thyroid, parathyroid glands, adrenals, and neuroendocrine pancreas are lined. distinct emphasis is at the detection, surgical operation, specified non-cytotoxic adjuvant treatment, surveillance, and genetics of those tumors.

Download e-book for kindle: The Official Patient's Sourcebook on Adult Hodgkin's by Icon Health Publications

This ebook has been created for sufferers who've made up our minds to make schooling and study a vital part of the remedy technique. even though it additionally provides info worthwhile to medical professionals, caregivers and different well-being execs, it tells sufferers the place and the way to seem for info overlaying nearly all subject matters with regards to grownup hodgkin's ailment (also melanoma Hodgkin's lymphoma; Hodgkin illness; Hodgkin's ailment; Hodgkin's Lymphoma; Lymphoma Hodgkin's; Malignant lymphoma), from the necessities to the main complex parts of study.

Download e-book for iPad: Stem Cell Research and Therapeutics (Advances in Biomedical by Yanhong Shi, Dennis Clegg

This publication is an up-to-date reference for the most fascinating fields of biomedical learn- Stem telephone learn and its healing functions. Stem mobilephone study holds nice promise for the remedy of many human ailments that at present lack powerful remedies. The set of chapters during this ebook offer insights into either easy stem mobile biology and scientific purposes of stem cell-based mobile alternative remedies for a number of human ailments, together with cardiovascular ailments, neurological issues, and liver degeneration.

Histological Typing of Tumours of the Central Nervous System - download pdf or read online

This moment variation displays the current degree of data and advances within the histological typing of tumours of the principal apprehensive process during the last thirteen years because the first version used to be released. The e-book is meant to advertise the adoption of a uniform terminology that might facilitate and increase conversation between melanoma employees.

Extra info for Anticancer drug development

Sample text

1999). A number of antisense approaches have also been used to implicate c-Src as an important facilitator of tumor cell proliferation in vitro and in vivo. , 1999). B. c-Src Interactions with Proliferative and Survival Signaling Pathways The mechanism by which c-Src influences tumor cell proliferation has been the subject of intense study. Although only limited evidence exists for the direct, single-agent, causative participation of overexpressed or overactive c-Src kinase in transforming events, many data support the participation of this kinase with other oncogenic signaling proteins and pathways (Fig.

And Prives, C. (2000). The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14, 289–300. 30 POMMIER, YU, AND KOHN Shieh, S. , and Prives, C. (1997). DNA damageinduced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91, 325–334. , and Terakawa, N. (2000). Mechanism of the combination effect of wild-type TP53 gene transfection and cisplatin treatment for ovarian cancer xenografts. Eur. J. Cancer 36, 1869–1875.

Cancer Res. 55, 3250–3253. , and Pommier, Y. (1999). Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the eight human breast cancer cell lines of the NCI anticancer drug screen: multifactorial relationship with topoisomerase I, protein kinase C, bcl-2 and caspase pathways. Int. J. Cancer 82, 396–404. , and Hoffmann, I. (2000). Cell cycle regulation by the Cdc25 phosphatase family. Prog. Cell. Cycle Res. 4, 107–114. Noble, M. E. and Endicott, J. A. (1999). Chemical inhibitors of cyclindependent kinases: Insights into design from X-ray crystallographic studies.

Download PDF sample

Anticancer drug development by Bruce C Baguley; David J Kerr


by Jason
4.2

Rated 4.84 of 5 – based on 12 votes