Download PDF by Eleazar Shafrir, Anders A F Sima: Animal Models in Diabetes: A Primer (Frontiers in Animal

By Eleazar Shafrir, Anders A F Sima

ISBN-10: 9058230961

ISBN-13: 9789058230966

Animal types of Diabetes: A Primer introduces features of the main ordinary animal species with a number of diabetic syndromes which were constructed and broadly investigated over the last few a long time. It comprises animal types which are available, good defined and confirmed to be of price within the learn of either kinds of diabetes. generally referenced, this booklet should be of worth to new and tested investigators, graduate scholars and pharmaceutical scientists engaged on the advance of antidiabetic and preventative modalities in a variety of parts of diabetes and its problems.

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Additional info for Animal Models in Diabetes: A Primer (Frontiers in Animal Diabetes Research)

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M. and Bellgrau, D. (1989) Thymus transplantation and disease prevention in the diabetes-prone BioBreeding rat. , 142, 3400–3405. C. and Bellgrau, D. (1988) T cell dysfunction in the diabetesprone BB rat. A role for thymic migrants that are not T cell precursors. J. Exp. , 167, 132–148. D. H. (1994) Multiple lowdose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Diabetes, 43, 433–440. , et al. (1998) Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/ Wor diabetic rat.

1998) Potential risk of oral insulin with adjuvant for the prevention of Type I diabetes: a protocol effective in NOD mice may exacerbate disease in BB rats. Diabetologia, 41, 844–847. , Vigeant, C. -F. (1994) Predictive value of lymphocyte antibodies for the appearance of diabetes in BB rats. Diabetes, 43, 137–142. , Olsson, T. and Lernmark, A. (1997) The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats. Diabetologia, 40, 786–792. , Cooke, A. D. (1990) Effect of cyclosporin on pancreatic events and development of diabetes in BB/Edinburgh rats.

1993), and the adenosine deaminase inhibitor, 2'-deoxycoformycin (dCF) (Thliveris et al, 1997). Other reagents targeted at macrophages including silica (Oschilewski et al, 1985) and deoxyspergualin (Di Marco et al, 1996) are also effective. Antibodies directed against various T cell subsets are also effective. , 1993) and also anti-CD2, which may act by depleting CD4+ T cells, preventing the activation of effector cells, or by blocking CD2/ligand interaction between effector and target cells (Barlow and Like, 1992).

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Animal Models in Diabetes: A Primer (Frontiers in Animal Diabetes Research) by Eleazar Shafrir, Anders A F Sima


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