Download e-book for kindle: Advances in Molecular Toxicology by James C. Fishbein (Eds.)

By James C. Fishbein (Eds.)

ISBN-10: 0444535845

ISBN-13: 9780444535849

Advances in Molecular Toxicology positive factors the most recent advances in the entire subspecialties of the huge quarter of molecular toxicology. Toxicology is the examine of toxins, and this sequence information the learn of the molecular foundation wherein an unlimited array of brokers encountered within the human atmosphere and produced by means of the human physique itself take place themselves as pollution. no longer strictly restricted to documenting those examples, the sequence can also be thinking about the advanced net of chemical and organic occasions that provide upward push to toxin-induced signs and ailment. the hot applied sciences which are being harnessed to research and comprehend those occasions can also be reviewed by means of top employees within the box. Advances in Molecular Toxicology will record growth in all points of those speedily evolving molecular features of toxicology with a view towards particular elucidation of either growth at the molecular point and on advances in technological techniques hired. * state of the art studies by way of major staff within the self-discipline. * In-depth dissection of molecular features of curiosity to a wide variety of scientists, physicians and any scholar within the allied disciplines. * cutting edge functions of technological techniques in chemistry, biochemistry and molecular drugs.

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Holian, Acrolein: A respiratory toxin that suppresses pulmonary host defense, Rev. Environ. Health 13 (1998) 99–108. [7] T. Morikawa, Acrolein, formaldehyde, and volatile fatty acids from smouldering combustion, J. Combust. Toxicol. 3 (1976) 135–151. P. Eiserich, A. J. Handelman, B. E. Cross, Dietary antioxidants and cigarette smoke-induced biomolecular damage: A complex interaction, Am. J. Clin. Nutr. 62 (1995) 1490S–1500S. I. Finkelstein, M. Nardini, A. van der Vliet, Inhibition of neutrophil apoptosis by acrolein: A mechanism of tobacco-related lung disease?

Savineau, R. Marthan, In vitro effect of air pollutants on human bronchi, Cell Biol. Toxicol. 18 (2002) 289–299. M. P. Savineau, R. Marthan, Selected contribution: Effect of the aldehyde acrolein on acetylcholine-induced membrane current in airway smooth muscle cells, J. Appl. Physiol. 90 (2001) 750–754. M. Hyvelin, E. C. P. Savineau, R. Marthan, Cellular mechanisms of acrolein-induced alteration in calcium signaling in airway smooth muscle, Toxicol. Appl. Pharmacol. 164 (2000) 176–183. A. D. Leikauf, Acrolein stimulates eicosanoid release from bovine airway epithelial cells, Am.

Nur77 may also translocate to the endoplasmic reticulum to activate a novel nonmitochondrial pathway of intrinsic apoptosis [120]. Moreover, Nur77 can activate receptor-mediated apoptosis in some cells [121,122]. Clearly, more work is needed to define the mechanisms of lung cell death prevailing under conditions of both chronic and acute acrolein exposure within the in vivo setting where little is known concerning the molecular events that mediate the epithelial damage elicited by smokeborne acrolein.

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Advances in Molecular Toxicology by James C. Fishbein (Eds.)

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